The Nam Bộ Boutique Hotel is a charming city hotel right at the Ninh Kiều pier, which offers seven suites and a small rooftop restaurant with a view, l'Escale. It offers fine market-inspired cuisine, a well-furnished wine cellar and quiet lounge with an unbeatable view of the river.
The building also hosts the Nam Bộ Restaurant, which offers a variety of both Vietnamese and Western dishes, tuned down a bit for the whole family.
See http://nambo.mekong-delta.com.
The Nam Bộ faces the river and the provinces bus boats, and is the perfect place to stay if you wish to be right at the center when comes the time to go out or in the early morning to take a boat to the floating market.